InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD79B

Summary

InnateDB Protein

IDBP-244934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD79B

Protein Name

CD79b molecule, immunoglobulin-associated beta

Synonyms

AGM6; B29; IGB;

Species

Homo sapiens

Ensembl Protein

ENSP00000376544

InnateDB Gene

IDBG-64384 (CD79B)

Protein Structure

UniProt Annotation

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269PubMed:12097390, ECO:0000269PubMed:8617796, ECO:0000269PubMed:9057631}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.

Disease Associations

Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269PubMed:17675462}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

B-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0019815	B cell receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF02189
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00077
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P40259