InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2R1

Summary

InnateDB Protein

IDBP-244980.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2R1

Protein Name

phospholipase A2 receptor 1, 180kDa

Synonyms

CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000376524

InnateDB Gene

IDBG-73343 (PLA2R1)

Protein Structure

UniProt Annotation

Function

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. {ECO:0000269PubMed:15611272, ECO:0000269PubMed:7721806}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Soluble secretory phospholipase A2 receptor: Secreted {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO:0000269PubMed:15611272, ECO:0000269PubMed:7721806, ECO:0000269PubMed:7925459, ECO:0000269PubMed:9481783}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0030246	carbohydrate binding
GO:0043274	phospholipase binding

Biological Process

GO:0001816	cytokine production
GO:0006898	receptor-mediated endocytosis
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0072593	reactive oxygen species metabolic process
GO:0090238	positive regulation of arachidonic acid secretion
GO:0090399	replicative senescence
GO:0090403	oxidative stress-induced premature senescence
GO:1900138	negative regulation of phospholipase A2 activity
GO:1900139	negative regulation of arachidonic acid secretion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000562 Fibronectin, type II, collagen-binding
IPR000772 Ricin B lectin domain
IPR001304 C-type lectin
IPR008646 Herpesvirus UL45-like
IPR013806 Kringle-like fold
IPR016187 C-type lectin fold

PFAM

PF00040
PF00652
PF14200
PF00059
PF05473

PRINTS

PIRSF

SMART

SM00059
SM00458
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13018