Version 5.4
Homo sapiens Gene: PLA2R1
Summary
InnateDB Gene IDBG-73343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2R1
Gene Name phospholipase A2 receptor 1, 180kDa
Synonyms CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R
Species Homo sapiens
Ensembl Gene ENSG00000153246
Encoded Proteins
IDBP-73345
phospholipase A2 receptor 1, 180kDa
IDBP-244980
phospholipase A2 receptor 1, 180kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:159932006-160062610
Strand Reverse strand
Band q24.2
Transcripts
ENST00000283243 ENSP00000283243
ENST00000392771 ENSP00000376524
ENST00000460710
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0030246 carbohydrate binding
GO:0043274 phospholipase binding
Biological Process
GO:0001816 cytokine production
GO:0006898 receptor-mediated endocytosis
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0072593 reactive oxygen species metabolic process
GO:0090238 positive regulation of arachidonic acid secretion
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
GO:1900138 negative regulation of phospholipase A2 activity
GO:1900139 negative regulation of arachidonic acid secretion
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054580
View Gene Order
ENSBTAG00000032515
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410477
RefSeq NM_001007267 NM_001195641 NM_007366 XM_005246392
HUGO
OMIM
CCDS CCDS33309 CCDS42767
HPRD 09222
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca