InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPN

Summary

InnateDB Protein

IDBP-24514.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPN

Protein Name

sialophorin

Synonyms

CD43; GALGP; GPL115; LSN;

Species

Homo sapiens

Ensembl Protein

ENSP00000353238

InnateDB Gene

IDBG-24512 (SPN)

Protein Structure

UniProt Annotation

Function

One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0001562	response to protozoan
GO:0001808	negative regulation of type IV hypersensitivity
GO:0001934	positive regulation of protein phosphorylation
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007162	negative regulation of cell adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0045060	negative thymic T cell selection
GO:0050688	regulation of defense response to virus
GO:0050776	regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0050900	leukocyte migration
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001931	uropod
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome