InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDON

Summary

InnateDB Protein

IDBP-245141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDON

Protein Name

Cdon homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376458

InnateDB Gene

IDBG-75707 (CDON)

Protein Structure

UniProt Annotation

Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269PubMed:21802063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001708	cell fate specification
GO:0001934	positive regulation of protein phosphorylation
GO:0002088	lens development in camera-type eye
GO:0007155	cell adhesion
GO:0007224	smoothened signaling pathway
GO:0007520	myoblast fusion
GO:0009952	anterior/posterior pattern specification
GO:0010172	embryonic body morphogenesis
GO:0014816	satellite cell differentiation
GO:0021987	cerebral cortex development
GO:0042692	muscle cell differentiation
GO:0043410	positive regulation of MAPK cascade
GO:0043497	regulation of protein heterodimerization activity
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048598	embryonic morphogenesis
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0051057	positive regulation of small GTPase mediated signal transduction
GO:0051146	striated muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4KMG0