InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSBG1

Summary

InnateDB Protein

IDBP-24520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSBG1

Protein Name

acyl-CoA synthetase bubblegum family member 1

Synonyms

BG; BG1; BGM; GR-LACS; LPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000258873

InnateDB Gene

IDBG-24518 (ACSBG1)

Protein Structure

UniProt Annotation

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. {ECO:0000269PubMed:10954726, ECO:0000269PubMed:12975357}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10954726}. Cytoplasmic vesicle {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269PubMed:10954726, ECO:0000269PubMed:12975357}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0031957	very long-chain fatty acid-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001552	ovarian follicle atresia
GO:0001676	long-chain fatty acid metabolic process
GO:0008152	metabolic process
GO:0042552	myelination
GO:0051384	response to glucocorticoid