InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RCHY1

Summary

InnateDB Protein

IDBP-24526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCHY1

Protein Name

ring finger and CHY zinc finger domain containing 1

Synonyms

ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363;

Species

Homo sapiens

Ensembl Protein

ENSP00000321239

InnateDB Gene

IDBG-24524 (RCHY1)

Protein Structure

UniProt Annotation

Function

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. {ECO:0000269PubMed:16914734, ECO:0000269PubMed:17721809, ECO:0000269PubMed:18006823, ECO:0000269PubMed:19043414, ECO:0000269PubMed:19483087, ECO:0000269PubMed:21791603, ECO:0000269PubMed:21994467}.

Subcellular Localization

Nucleus. Nucleus speckle. Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	96 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865	protein autoubiquitination