InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPRC5C

Summary

InnateDB Protein

IDBP-245276.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPRC5C

Protein Name

G protein-coupled receptor, family C, group 5, member C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376403

InnateDB Gene

IDBG-67203 (GPRC5C)

Protein Structure

UniProt Annotation

Function

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.

Disease Associations

Tissue Specificity

Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG). {ECO:0000269PubMed:10945465, ECO:0000269PubMed:11311935}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186

G-protein coupled receptor signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome