InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDK1

Summary

InnateDB Protein

IDBP-245392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDK1

Protein Name

pyruvate dehydrogenase kinase, isozyme 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376352

InnateDB Gene

IDBG-75174 (PDK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006006	glucose metabolic process
GO:0006090	pyruvate metabolic process
GO:0006468	protein phosphorylation
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0016310	phosphorylation
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005967	mitochondrial pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

InterPro

IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR005467 Signal transduction histidine kinase, core
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

PFAM

PF02518
PF13581
PF10436

PRINTS

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15118