InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CIT

Summary

InnateDB Protein

IDBP-245485.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIT

Protein Name

citron (rho-interacting, serine/threonine kinase 21)

Synonyms

CRIK; STK21;

Species

Homo sapiens

Ensembl Protein

ENSP00000376306

InnateDB Gene

IDBG-60008 (CIT)

Protein Structure

UniProt Annotation

Function

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269PubMed:16236794, ECO:0000269PubMed:16431929, ECO:0000269PubMed:21457715}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0017124	SH3 domain binding
GO:0030165	PDZ domain binding
GO:0046872	metal ion binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000910	cytokinesis
GO:0006468	protein phosphorylation
GO:0007030	Golgi organization
GO:0007067	mitotic nuclear division
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0008064	regulation of actin polymerization or depolymerization
GO:0016358	dendrite development
GO:0035556	intracellular signal transduction
GO:0048699	generation of neurons
GO:0050774	negative regulation of dendrite morphogenesis
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005773	vacuole
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0031985	Golgi cisterna
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000533 Tropomyosin
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011072 HR1 rho-binding repeat
IPR017405 Citron Rho-interacting kinase
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM