InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYNLL1

Summary

InnateDB Protein

IDBP-245520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNLL1

Protein Name

dynein, light chain, LC8-type 1

Synonyms

DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8; LC8a; PIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000376297

InnateDB Gene

IDBG-60661 (DYNLL1)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Subcellular Localization

Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:8628263}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	131 [view]
Protein-Protein	131 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006915	apoptotic process
GO:0007017	microtubule-based process
GO:0007292	female gamete generation
GO:0009653	anatomical structure morphogenesis
GO:0016032	viral process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0021762	substantia nigra development
GO:0030036	actin cytoskeleton organization
GO:0042326	negative regulation of phosphorylation
GO:0050790	regulation of catalytic activity
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0072686	mitotic spindle