InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DYNLL1

Summary

InnateDB Gene

IDBG-60661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNLL1

Gene Name

dynein, light chain, LC8-type 1

Synonyms

DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8; LC8a; PIN

Species

Homo sapiens

Ensembl Gene

ENSG00000088986

Encoded Proteins

IDBP-60663

dynein, light chain, LC8-type 1

IDBP-245520

dynein, light chain, LC8-type 1

IDBP-245522

dynein, light chain, LC8-type 1

IDBP-585645

dynein, light chain, LC8-type 1

IDBP-590907

dynein, light chain, LC8-type 1

IDBP-602079

dynein, light chain, LC8-type 1

IDBP-597825

dynein, light chain, LC8-type 1

IDBP-603648

dynein, light chain, LC8-type 1

IDBP-585053

dynein, light chain, LC8-type 1

IDBP-600595

dynein, light chain, LC8-type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:120469850-120498493

Strand

Forward strand

Band

q24.31

Transcripts

ENST00000242577	ENSP00000242577
ENST00000392509	ENSP00000376297
ENST00000392508	ENSP00000376296
ENST00000549649	ENSP00000448834
ENST00000548342	ENSP00000447907
ENST00000548214	ENSP00000448608
ENST00000550178	ENSP00000446596
ENST00000550845	ENSP00000447494
ENST00000549989	ENSP00000446614
ENST00000552870	ENSP00000449088
ENST00000552316

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	131 [view]
Protein-Protein	131 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006915	apoptotic process
GO:0007017	microtubule-based process
GO:0007292	female gamete generation
GO:0009653	anatomical structure morphogenesis
GO:0016032	viral process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0021762	substantia nigra development
GO:0030036	actin cytoskeleton organization
GO:0042326	negative regulation of phosphorylation
GO:0050790	regulation of catalytic activity
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0072686	mitotic spindle