InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRSF2

Summary

InnateDB Protein

IDBP-245561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF2

Protein Name

serine/arginine-rich splicing factor 2

Synonyms

PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b;

Species

Homo sapiens

Ensembl Protein

ENSP00000376276

InnateDB Gene

IDBG-70058 (SRSF2)

Protein Structure

UniProt Annotation

Function

Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269PubMed:19592491, ECO:0000269PubMed:21157427}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269PubMed:21157427}. Nucleus speckle {ECO:0000269PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	97 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:2001141	regulation of RNA biosynthetic process