InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAFG

Summary

InnateDB Protein

IDBP-245809.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAFG

Protein Name

v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)

Synonyms

hMAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000376173

InnateDB Gene

IDBG-72865 (MAFG)

Protein Structure

UniProt Annotation

Function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:11154691}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle. Also expressed in heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity