InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAFG

Summary

InnateDB Gene

IDBG-72865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAFG

Gene Name

v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)

Synonyms

hMAF

Species

Homo sapiens

Ensembl Gene

ENSG00000197063

Encoded Proteins

IDBP-72867

v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)

IDBP-245809

v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)

IDBP-759284

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81918270-81927714

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000357736	ENSP00000350369
ENST00000392366	ENSP00000376173
ENST00000574686	ENSP00000459634

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0030534	adult behavior
GO:0030641	regulation of cellular pH
GO:0042127	regulation of cell proliferation
GO:0045604	regulation of epidermal cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000051510

View Gene Order

ENSBTAG00000000040

Not yet available

Pathways

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

ap1_pathway

AP-1 transcription factor network

Cross-References

SwissProt

O15525

TrEMBL

A0A024R8X1 I3L2F8

UniProt Splice Variant

Entrez Gene

4097

UniGene

Hs.252229 Hs.596676 Hs.602336 Hs.732854 Hs.743366

RefSeq

NM_002359 NM_032711 XM_006722282

HUGO

HGNC:6781

OMIM

602020

CCDS

CCDS11793

HPRD

IMGT

EMBL

AC145207 AF059195 BC012327 CH471099 U84249 Y11514

GenPept

AAC14427 AAC51737 AAH12327 CAA72284 EAW89712 EAW89715

RNA Seq Atlas

4097