InnateDB Protein
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IDBP-246028.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IYD
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Protein Name
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iodotyrosine deiodinase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376085
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InnateDB Gene
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IDBG-97878 (IYD)
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Protein Structure
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Function |
Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. {ECO:0000269PubMed:15289438}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:15289438}; Single-pass membrane protein {ECO:0000269PubMed:15289438}.
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Disease Associations |
Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism. {ECO:0000269PubMed:18434651}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed at a high level in thyroid gland and at lower level in kidney and trachea. {ECO:0000269PubMed:15289438}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0016491
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oxidoreductase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000415
Nitroreductase-like
IPR029479
Nitroreductase
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PFAM |
PF00881
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PHW0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
389434
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UniGene |
Hs.593957
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RefSeq |
NP_001158167
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HUGO |
HGNC:21071
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OMIM |
612025
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CCDS |
CCDS55066
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HPRD |
16668
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IMGT |
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EMBL |
AK129950
AL031010
AY259176
AY259177
AY424901
AY424902
AY957659
AY957660
AY957661
BC056253
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GenPept |
AAH56253
AAP22072
AAP22073
AAR84259
AAR84260
AAY41465
AAY41466
AAY41467
BAC85255
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