Version 5.4
| Homo sapiens Gene: IYD | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-97878.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | IYD | ||||||||
| Gene Name | iodotyrosine deiodinase | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000009765 | ||||||||
| Encoded Proteins |
iodotyrosine deiodinase
iodotyrosine deiodinase
iodotyrosine deiodinase
iodotyrosine deiodinase
iodotyrosine deiodinase
iodotyrosine deiodinase
iodotyrosine deiodinase
iodotyrosine deiodinase
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 6:150368892-150405969 | ||||||||
| Strand | Forward strand | ||||||||
| Band | q25.1 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Thyroxine biosynthesis pathway
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Hs.310225 Hs.544367 Hs.593957 | ||||||||
| RefSeq | NM_001164694 NM_001164695 NM_203395 XM_006715478 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | CCDS5227 CCDS55066 CCDS55067 | ||||||||
| HPRD | 16668 | ||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||