Version 5.4
Homo sapiens Protein: PYHIN1
Summary
InnateDB Protein IDBP-246036.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYHIN1
Protein Name pyrin and HIN domain family, member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376083
InnateDB Gene IDBG-103841 (PYHIN1)
Protein Structure
UniProt Annotation
Function Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269PubMed:16479015, ECO:0000269PubMed:18247378}.
Subcellular Localization Isoform 1: Nucleus, nucleoplasm.Isoform 3: Nucleus, nucleoplasm.Isoform 5: Nucleus. Nucleus speckle.
Disease Associations
Tissue Specificity Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269PubMed:15122330}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR004020 DAPIN domain
IPR004021 HIN-200/IF120x
IPR011029 Death-like domain
PFAM PF02758
PF02760
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6K0P9
PhosphoSite PhosphoSite-Q6K0P9
TrEMBL X6RHR0
UniProt Splice Variant
Entrez Gene 149628
UniGene Hs.734876
RefSeq NP_945147
HUGO HGNC:28894
OMIM 612677
CCDS CCDS30907
HPRD 09999
IMGT
EMBL AL359753 AY185344 AY185345 AY185346 AY185347 BC020822 BC090944 BC139741 CH471121
GenPept AAH20822 AAH90944 AAI39742 AAO67506 AAO67507 AAO67508 AAO67509 CAI15075 CAI15076 CAI15077 CAI15078 CAI15079 CAI15080 EAW52805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca