Version 5.4
Homo sapiens Protein: STRADB
Summary
InnateDB Protein IDBP-246042.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STRADB
Protein Name STE20-related kinase adaptor beta
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376080
InnateDB Gene IDBG-78683 (STRADB)
Protein Structure
UniProt Annotation
Function Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14517248}. Cytoplasm {ECO:0000269PubMed:14517248}.
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle, testis, liver and colon. {ECO:0000269PubMed:11161814, ECO:0000269PubMed:12048196}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0007050 cell cycle arrest
GO:0008286 insulin receptor signaling pathway
GO:0032147 activation of protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C0K7
PhosphoSite PhosphoSite-Q9C0K7
TrEMBL
UniProt Splice Variant
Entrez Gene 55437
UniGene Hs.652338
RefSeq NP_001193793
HUGO HGNC:13205
OMIM 607333
CCDS CCDS56161
HPRD 09546
IMGT
EMBL AB038950 AC007282 AF116618 AK027637 AY093697 BC008302 BC090871
GenPept AAF71042 AAH08302 AAH90871 AAM19143 AAY14692 BAB32500 BAB55254

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca