InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAG

Summary

InnateDB Protein

IDBP-246118.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAG

Protein Name

myelin associated glycoprotein

Synonyms

GMA; S-MAG; SIGLEC-4A; SIGLEC4A;

Species

Homo sapiens

Ensembl Protein

ENSP00000376048

InnateDB Gene

IDBG-43939 (MAG)

Protein Structure

UniProt Annotation

Function

Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0021762	substantia nigra development
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0033270	paranode region of axon
GO:0043209	myelin sheath
GO:0043220	Schmidt-Lanterman incisure

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20916