Version 5.4
Homo sapiens Gene: MAG
Summary
InnateDB Gene IDBG-43939.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAG
Gene Name myelin associated glycoprotein
Synonyms GMA; S-MAG; SIGLEC-4A; SIGLEC4A
Species Homo sapiens
Ensembl Gene ENSG00000105695
Encoded Proteins
IDBP-43941
myelin associated glycoprotein
IDBP-246118
myelin associated glycoprotein
IDBP-588941
myelin associated glycoprotein
IDBP-760747
IDBP-766210
IDBP-760417
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35292125-35313804
Strand Forward strand
Band q13.12
Transcripts
ENST00000361922 ENSP00000355234
ENST00000392213 ENSP00000376048
ENST00000537831 ENSP00000440695
ENST00000597035 ENSP00000473245
ENST00000597162
ENST00000595791 ENSP00000473125
ENST00000600291 ENSP00000470772
ENST00000593348
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0021762 substantia nigra development
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0033270 paranode region of axon
GO:0043209 myelin sheath
GO:0043220 Schmidt-Lanterman incisure
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036634
View Gene Order
ENSBTAG00000017044
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0R3I4
UniProt Splice Variant
Entrez Gene 4099
UniGene Hs.643440
RefSeq NM_001199216 NM_002361 NM_080600
HUGO HGNC:6783
OMIM 159460
CCDS CCDS12455 CCDS12456 CCDS56090
HPRD 01160
IMGT
EMBL AC002132 AD000684
GenPept
RNA Seq Atlas 4099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca