InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX9

Summary

InnateDB Protein

IDBP-246173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX9

Protein Name

sorting nexin 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376024

InnateDB Gene

IDBG-98390 (SNX9)

Protein Structure

UniProt Annotation

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269PubMed:11799118, ECO:0000269PubMed:12952949, ECO:0000269PubMed:15703209, ECO:0000269PubMed:17609109, ECO:0000269PubMed:17948057, ECO:0000269PubMed:18388313, ECO:0000269PubMed:20427313, ECO:0000269PubMed:21048941, ECO:0000269PubMed:22718350}.

Subcellular Localization

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. {ECO:0000269PubMed:10531379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	46 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0031625	ubiquitin protein ligase binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0032461	positive regulation of protein oligomerization
GO:0036089	cleavage furrow formation
GO:0043547	positive regulation of GTPase activity
GO:0060988	lipid tube assembly

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030136	clathrin-coated vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
IPR014536 Sorting nexin 9 subfamily
IPR019497 Sorting nexin protein, WASP-binding domain

PFAM

PF00018
PF14604
PF00787
PF07653
PF10456

PRINTS

PR00452

PIRSF

PIRSF027744

SMART

SM00326
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References