InnateDB Protein
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IDBP-246378.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DNAJB2
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Protein Name
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DnaJ (Hsp40) homolog, subfamily B, member 2
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Synonyms
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DSMA5; HSJ-1; HSJ1; HSPF3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375936
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InnateDB Gene
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IDBG-81509 (DNAJB2)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired. {ECO:0000269PubMed:22522442}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Brain (neuronal layers). Weakly, in skeletal muscle and spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006457
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protein folding
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GO:0006986
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response to unfolded protein
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GO:0008219
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cell death
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GO:0008285
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negative regulation of cell proliferation
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GO:0030308
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negative regulation of cell growth
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GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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GO:0031398
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positive regulation of protein ubiquitination
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GO:0032436
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positive regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0042026
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protein refolding
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GO:0090084
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negative regulation of inclusion body assembly
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GO:0090086
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negative regulation of protein deubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR001623
DnaJ domain
IPR003903
Ubiquitin interacting motif
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PFAM |
PF00226
PF02809
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PRINTS |
PR00625
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PIRSF |
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SMART |
SM00271
SM00726
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TIGRFAMs |
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Modification |
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SwissProt |
P25686
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PhosphoSite |
PhosphoSite-P25686
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TrEMBL |
C9JX00
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UniProt Splice Variant |
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Entrez Gene |
3300
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UniGene |
Hs.77768
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RefSeq |
NP_001034639
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HUGO |
HGNC:5228
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OMIM |
604139
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CCDS |
CCDS46519
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HPRD |
07249
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IMGT |
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EMBL |
AC114803
AK292761
BC011609
BC047056
BT007088
S37374
S37375
X63368
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GenPept |
AAA09034
AAA09035
AAH11609
AAH47056
AAP35751
BAF85450
CAA44968
CAA44969
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