InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG16L1

Summary

InnateDB Protein

IDBP-246510.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG16L1

Protein Name

ATG16 autophagy related 16-like 1 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375875

InnateDB Gene

IDBG-83447 (ATG16L1)

Protein Structure

UniProt Annotation

Function

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. {ECO:0000269PubMed:23376921, ECO:0000269PubMed:24553140}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Disease Associations

Inflammatory bowel disease 10 (IBD10) [MIM:611081]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269PubMed:17200669, ECO:0000269PubMed:17435756}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0015031	protein transport
GO:0045087	innate immune response (InnateDB)
GO:0051260	protein homooligomerization

Cellular Component

GO:0005776	autophagic vacuole
GO:0005930	axoneme
GO:0034045	pre-autophagosomal structure membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR009053 Prefoldin
IPR013923 Autophagy-related protein 16
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08614

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt