Version 5.4
Homo sapiens Gene: ATG16L1
Summary
InnateDB Gene IDBG-83447.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG16L1
Gene Name autophagy related 16-like 1 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085978
Encoded Proteins
IDBP-83451
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-83455
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-246508
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-246510
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-246512
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-246514
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-389365
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-389366
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-389367
ATG16 autophagy related 16-like 1 (S. cerevisiae)
IDBP-389368
ATG16 autophagy related 16-like 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19898471
ATG16L1 is involved in autophagy where it is recruited to the plasma membrane at the site of bacterial entry by NOD1 and NOD2.
PMID 20200479
ATG16L1, a critical autophagy protein, is recruited to the plasma membrane by NOD2 during bacterial invasion.
Entrez Gene
Summary The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:233210051-233295674
Strand Forward strand
Band q37.1
Transcripts
ENST00000347464 ENSP00000318259
ENST00000373525 ENSP00000362625
ENST00000392021 ENSP00000375876
ENST00000392020 ENSP00000375875
ENST00000392018 ENSP00000375873
ENST00000392017 ENSP00000375872
ENST00000431917 ENSP00000397512
ENST00000444735 ENSP00000409215
ENST00000419681 ENSP00000398773
ENST00000417017 ENSP00000412046
ENST00000479942
ENST00000485623
ENST00000474148
ENST00000498620
ENST00000492298
ENST00000464645
ENST00000472242
ENST00000473865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0015031 protein transport
GO:0039689 negative stranded viral RNA replication
GO:0045087 innate immune response (InnateDB)
GO:0051260 protein homooligomerization
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005776 autophagic vacuole
GO:0005930 axoneme
GO:0034045 pre-autophagosomal structure membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026289
View Gene Order
ENSBTAG00000003928
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529322
RefSeq NM_001190266 NM_001190267 NM_017974 NM_030803 NM_198890 XM_005246082
HUGO
OMIM
CCDS CCDS2502 CCDS2503 CCDS54438
HPRD 16498
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca