InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPUL1

Summary

InnateDB Protein

IDBP-246534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPUL1

Protein Name

heterogeneous nuclear ribonucleoprotein U-like 1

Synonyms

E1B-AP5; E1BAP5; HNRPUL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000375863

InnateDB Gene

IDBG-52711 (HNRNPUL1)

Protein Structure

UniProt Annotation

Function

Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269PubMed:12489984, ECO:0000269PubMed:9733834}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11513728, ECO:0000269PubMed:12489984, ECO:0000269PubMed:9733834}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	123 [view]
Protein-Protein	120 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0009615	response to virus
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001870 B30.2/SPRY domain
IPR003034 SAP domain
IPR003877 SPRY domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02037
PF00622

PRINTS

PIRSF

SMART

SM00513
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BUJ2