Version 5.4
Homo sapiens Protein: DENND1B
Summary
InnateDB Protein IDBP-246599.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1B
Protein Name DENN/MADD domain containing 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000375839
InnateDB Gene IDBG-246597 (DENND1B)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) for RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. May play a role in clathrin- mediated endocytosis. {ECO:0000269PubMed:20154091, ECO:0000269PubMed:20937701}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T- cells as compared with naive T-cells. {ECO:0000269PubMed:20032318}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q6P3S1
TrEMBL X6RAS2
UniProt Splice Variant
Entrez Gene 163486
UniGene Hs.743766
RefSeq
HUGO HGNC:28404
OMIM 613292
CCDS
HPRD 13303
IMGT
EMBL AL139136 AL365258
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca