InnateDB Protein
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IDBP-24664.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANGPTL4
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Protein Name
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angiopoietin-like 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000301455
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InnateDB Gene
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IDBG-24662 (ANGPTL4)
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Protein Structure
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Function |
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:10698685}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269PubMed:10698685, ECO:0000269PubMed:12015030}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
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PFAM |
PF00147
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BY76
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PhosphoSite |
PhosphoSite-Q9BY76
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TrEMBL |
M0R3A2
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UniProt Splice Variant |
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Entrez Gene |
51129
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UniGene |
Hs.9613
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RefSeq |
NP_647475
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HUGO |
HGNC:16039
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OMIM |
605910
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CCDS |
CCDS12200
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HPRD |
16173
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IMGT |
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EMBL |
AB056477
AC136469
AF153606
AF169312
AF202636
AK222489
AK222524
AK303269
AY358275
BC023647
CH471139
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GenPept |
AAD41088
AAF62868
AAG22490
AAH23647
AAQ88642
BAB40692
BAD96209
BAD96244
BAG64351
EAW68930
EAW68931
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