Version 5.4
Homo sapiens Gene: ANGPTL4
Summary
InnateDB Gene IDBG-24662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPTL4
Gene Name angiopoietin-like 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167772
Encoded Proteins
IDBP-24664
angiopoietin-like 4
IDBP-242549
angiopoietin-like 4
IDBP-765101
IDBP-762728
IDBP-760379
IDBP-765489
IDBP-761079
IDBP-762305
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:8363289-8374373
Strand Forward strand
Band p13.2
Transcripts
ENST00000301455 ENSP00000301455
ENST00000393962 ENSP00000377534
ENST00000601770 ENSP00000471345
ENST00000594348
ENST00000593998 ENSP00000472551
ENST00000597137
ENST00000595079 ENSP00000473025
ENST00000601886 ENSP00000470307
ENST00000599192 ENSP00000473090
ENST00000594875 ENSP00000472869
ENST00000598255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0030154 cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045766 positive regulation of angiogenesis
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0051260 protein homooligomerization
GO:0070328 triglyceride homeostasis
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002289
View Gene Order
ENSBTAG00000002473
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9BY76
TrEMBL M0QZ51 M0R0N8 M0R3A2
UniProt Splice Variant
Entrez Gene 51129
UniGene Hs.737500 Hs.9613
RefSeq NM_001039667 NM_139314
HUGO HGNC:16039
OMIM 605910
CCDS CCDS12200 CCDS42493
HPRD 16173
IMGT
EMBL AB056477 AC136469 AF153606 AF169312 AF202636 AK222489 AK222524 AK303269 AY358275 BC023647 CH471139
GenPept AAD41088 AAF62868 AAG22490 AAH23647 AAQ88642 BAB40692 BAD96209 BAD96244 BAG64351 EAW68930 EAW68931
RNA Seq Atlas 51129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca