InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IREB2

Summary

InnateDB Protein

IDBP-24670.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IREB2

Protein Name

iron-responsive element binding protein 2

Synonyms

ACO3; IRP2; IRP2AD;

Species

Homo sapiens

Ensembl Protein

ENSP00000258886

InnateDB Gene

IDBG-24668 (IREB2)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269PubMed:7983023}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030350	iron-responsive element binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006417	regulation of translation
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0007568	aging
GO:0008152	metabolic process
GO:0009791	post-embryonic development
GO:0010040	response to iron(II) ion
GO:0010468	regulation of gene expression
GO:0030316	osteoclast differentiation
GO:0032526	response to retinoic acid
GO:0034101	erythrocyte homeostasis
GO:0050892	intestinal absorption
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR006249 Aconitate/iron regulatory protein 2
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel

PFAM

PF00694
PF00330

PRINTS

PR00415

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48200