Version 5.4
Homo sapiens Gene: IREB2
Summary
InnateDB Gene IDBG-24668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IREB2
Gene Name iron-responsive element binding protein 2
Synonyms ACO3; IRP2; IRP2AD
Species Homo sapiens
Ensembl Gene ENSG00000136381
Encoded Proteins
IDBP-24670
iron-responsive element binding protein 2
IDBP-600233
iron-responsive element binding protein 2
IDBP-594523
iron-responsive element binding protein 2
IDBP-594706
iron-responsive element binding protein 2
IDBP-599317
iron-responsive element binding protein 2
IDBP-590158
iron-responsive element binding protein 2
IDBP-593842
iron-responsive element binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26190773
[Mus musculus] Macrophage iron regulatory proteins Aco1 and Ireb2 are protective against Salmonella by promoting the induction of Lcn2, a host antimicrobial factor that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78437431-78501456
Strand Forward strand
Band q25.1
Transcripts
ENST00000258886 ENSP00000258886
ENST00000560840 ENSP00000453172
ENST00000559215 ENSP00000453532
ENST00000558525 ENSP00000453058
ENST00000560440 ENSP00000452938
ENST00000558570 ENSP00000454063
ENST00000560454
ENST00000559427
ENST00000559676
ENST00000559091 ENSP00000453863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006417 regulation of translation
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0007568 aging
GO:0008152 metabolic process
GO:0009791 post-embryonic development
GO:0010040 response to iron(II) ion
GO:0010468 regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0032526 response to retinoic acid
GO:0034101 erythrocyte homeostasis
GO:0050892 intestinal absorption
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032293
View Gene Order
ENSBTAG00000002504
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL H0YLE0
UniProt Splice Variant
Entrez Gene 3658
UniGene Hs.436031 Hs.607414 Hs.619090
RefSeq NM_004136
HUGO HGNC:6115
OMIM 147582
CCDS CCDS10302
HPRD 08858
IMGT
EMBL AC011270 AC027228
GenPept
RNA Seq Atlas 3658

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca