Version 5.4
Homo sapiens Protein: SREK1
Summary
InnateDB Protein IDBP-24673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SREK1
Protein Name splicing regulatory glutamine/lysine-rich protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000370305
InnateDB Gene IDBG-24671 (SREK1)
Protein Structure
UniProt Annotation
Function Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXA9
PhosphoSite PhosphoSite-Q8WXA9
TrEMBL Q69YM5
UniProt Splice Variant
Entrez Gene 140890
UniGene Hs.717970
RefSeq NP_631907
HUGO HGNC:17882
OMIM 609268
CCDS CCDS3991
HPRD 18043
IMGT
EMBL AC008772 AC025442 AF459094 AL832888 BC047322 BC067770 BC112343
GenPept AAH47322 AAH67770 AAI12344 AAL67778 CAH10414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca