InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DACT3

Summary

InnateDB Protein

IDBP-246730.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DACT3

Protein Name

dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375783

InnateDB Gene

IDBG-58901 (DACT3)

Protein Structure

UniProt Annotation

Function

May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269PubMed:18538736}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051018	protein kinase A binding
GO:0070097	delta-catenin binding

Biological Process

GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0035414	negative regulation of catenin import into nucleus
GO:0090090	negative regulation of canonical Wnt signaling pathway