InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNK2

Summary

InnateDB Protein

IDBP-246768.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNK2

Protein Name

potassium channel, subfamily K, member 2

Synonyms

hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK; TREK-1; TREK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000375764

InnateDB Gene

IDBG-106654 (KCNK2)

Protein Structure

UniProt Annotation

Function

Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. {ECO:0000269PubMed:10784345, ECO:0000269PubMed:11319556, ECO:0000269PubMed:24196565}.Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.Isoform 4: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. {ECO:0000269PubMed:24196565}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015271	outward rectifier potassium channel activity
GO:0019870	potassium channel inhibitor activity
GO:0022841	potassium ion leak channel activity

Biological Process

GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR003976 Two pore domain potassium channel, TREK
IPR008074 Two pore domain potassium channel, TRAAK
IPR013099 Two pore domain potassium channel domain

PFAM

PF07885

PRINTS

PR01095
PR01333
PR01499
PR01691

PIRSF

PIRSF038061

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt