InnateDB Protein
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IDBP-246945.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KLK6
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Protein Name
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kallikrein-related peptidase 6
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Synonyms
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Bssp; hK6; Klk7; PRSS18; PRSS9; SP59;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375684
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InnateDB Gene
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IDBG-65226 (KLK6)
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Protein Structure
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Function |
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269PubMed:11983703, ECO:0000269PubMed:12878203, ECO:0000269PubMed:12928483, ECO:0000269PubMed:15557757, ECO:0000269PubMed:16321973, ECO:0000269PubMed:16987227}.
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Subcellular Localization |
Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
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Disease Associations |
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Tissue Specificity |
In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. {ECO:0000269PubMed:10997858, ECO:0000269PubMed:11018688, ECO:0000269PubMed:11668196, ECO:0000269PubMed:12928483, ECO:0000269PubMed:16800739}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
Q92876
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5653
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UniGene |
Hs.79361
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RefSeq |
NP_001012983
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HUGO |
HGNC:6367
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OMIM |
602652
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CCDS |
CCDS42599
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HPRD |
04037
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IMGT |
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EMBL |
AC011483
AF013988
AF149289
AF243527
AK314897
AY318867
AY318868
AY318869
AY318870
BC015525
BT006852
CH471135
D78203
DQ223012
U62801
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GenPept |
AAB07113
AAB66483
AAD51475
AAG33359
AAH15525
AAP35498
AAP82446
AAP82448
ABB04464
BAA11306
BAG37411
EAW71953
EAW71954
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