Version 5.4
Homo sapiens Gene: KLK6
Summary
InnateDB Gene IDBG-65226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK6
Gene Name kallikrein-related peptidase 6
Synonyms Bssp; hK6; Klk7; PRSS18; PRSS9; SP59
Species Homo sapiens
Ensembl Gene ENSG00000167755
Encoded Proteins
IDBP-65228
kallikrein-related peptidase 6
IDBP-65230
kallikrein-related peptidase 6
IDBP-65232
kallikrein-related peptidase 6
IDBP-246945
kallikrein-related peptidase 6
IDBP-759794
IDBP-761870
IDBP-764242
IDBP-765258
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer\'s disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50958631-50969673
Strand Reverse strand
Band q13.41
Transcripts
ENST00000310157 ENSP00000309148
ENST00000376853 ENSP00000366049
ENST00000376851 ENSP00000366047
ENST00000391808 ENSP00000375684
ENST00000594641 ENSP00000470482
ENST00000597379 ENSP00000469630
ENST00000599881 ENSP00000471948
ENST00000599690 ENSP00000469702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007417 central nervous system development
GO:0009611 response to wounding
GO:0010975 regulation of neuron projection development
GO:0016540 protein autoprocessing
GO:0030574 collagen catabolic process
GO:0042246 tissue regeneration
GO:0042445 hormone metabolic process
GO:0042552 myelination
GO:0042982 amyloid precursor protein metabolic process
GO:0045595 regulation of cell differentiation
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0070997 neuron death
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0015630 microtubule cytoskeleton
GO:0030141 secretory granule
GO:0031965 nuclear membrane
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050063
View Gene Order
ENSBTAG00000030482
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.79361
RefSeq NM_001012964 NM_001012965 NM_002774
HUGO
OMIM
CCDS CCDS12811 CCDS42599
HPRD 04037
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca