Version 5.4
Homo sapiens Protein: LILRB4
Summary
InnateDB Protein IDBP-247091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LILRB4
Protein Name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Synonyms CD85K; ILT-3; ILT3; LIR-5; LIR5;
Species Homo sapiens
Ensembl Protein ENSP00000375616
InnateDB Gene IDBG-68893 (LILRB4)
Protein Structure
UniProt Annotation
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269PubMed:11875462, ECO:0000269PubMed:9151699}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Disease Associations
Tissue Specificity Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. {ECO:0000269PubMed:9151699, ECO:0000269PubMed:9278324, ECO:0000269PubMed:9548455}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0007165 signal transduction
GO:0045671 negative regulation of osteoclast differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin
PFAM PF00047
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHJ6
PhosphoSite PhosphoSite-Q8NHJ6
TrEMBL
UniProt Splice Variant
Entrez Gene 11006
UniGene Hs.67846
RefSeq NP_001265359
HUGO HGNC:6608
OMIM 604821
CCDS CCDS12902
HPRD 11996
IMGT
EMBL AC009892 AC011515 AF025532 AF189768 AF283988 BC026309 CR542048 CR609786 U91925
GenPept AAB68665 AAB87666 AAG02024 AAH26309 AAL36992 CAG46845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca