InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARCH2

Summary

InnateDB Protein

IDBP-24764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARCH2

Protein Name

membrane-associated ring finger (C3HC4) 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215555

InnateDB Gene

IDBG-24762 (MARCH2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. {ECO:0000269PubMed:14722266, ECO:0000269PubMed:15689499, ECO:0000269PubMed:16428329}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:14722266}; Multi-pass membrane protein {ECO:0000269PubMed:14722266}. Lysosome membrane {ECO:0000269PubMed:14722266}; Multi-pass membrane protein {ECO:0000269PubMed:14722266}. Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Broadly expressed. {ECO:0000269PubMed:14722266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006897	endocytosis
GO:0016567	protein ubiquitination

Cellular Component

GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle