Version 5.4
Homo sapiens Gene: MARCH2
Summary
InnateDB Gene IDBG-24762.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH2
Gene Name membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099785
Encoded Proteins
IDBP-24764
membrane-associated ring finger (C3HC4) 2
IDBP-24766
membrane-associated ring finger (C3HC4) 2
IDBP-763234
IDBP-760947
IDBP-762922
IDBP-765413
IDBP-760265
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:8413270-8439017
Strand Forward strand
Band p13.2
Transcripts
ENST00000215555 ENSP00000215555
ENST00000381035 ENSP00000370423
ENST00000602117 ENSP00000471536
ENST00000595142 ENSP00000472027
ENST00000601283 ENSP00000469386
ENST00000595213 ENSP00000471411
ENST00000594796
ENST00000601724 ENSP00000471619
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0016567 protein ubiquitination
Cellular Component
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079557
View Gene Order
ENSBTAG00000021036
Not yet available
Cross-References
SwissProt
TrEMBL M0QXU4
UniProt Splice Variant
Entrez Gene 51257
UniGene Hs.619960 Hs.631861
RefSeq NM_001005415 NM_001005416 NM_016496 XM_006722762 XM_006722763
HUGO HGNC:28038
OMIM 613332
CCDS CCDS12202 CCDS32894
HPRD 14361
IMGT
EMBL AC136469
GenPept
RNA Seq Atlas 51257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca