InnateDB Protein
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IDBP-24812.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HNRNPM
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Protein Name
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heterogeneous nuclear ribonucleoprotein M
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Synonyms
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CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000325376
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InnateDB Gene
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IDBG-24810 (HNRNPM)
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Protein Structure
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Function |
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000269Ref.5}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 243 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
243
[view]
|
Protein-Protein |
243
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR024666
Heterogeneous nuclear ribonucleoprotein M, PY nuclear localisation signal
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PFAM |
PF00076
PF11532
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P52272
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PhosphoSite |
PhosphoSite-P52272
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TrEMBL |
Q8TCM5
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UniProt Splice Variant |
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Entrez Gene |
4670
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UniGene |
Hs.608878
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RefSeq |
NP_005959
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HUGO |
HGNC:5046
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OMIM |
160994
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CCDS |
CCDS12203
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HPRD |
01188
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IMGT |
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EMBL |
AF061832
AL713781
BC000138
BC008895
BC019580
L03532
L32611
X72018
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GenPept |
AAA36192
AAC16002
AAH00138
AAH08895
AAH19580
AAL31359
CAA50897
CAD28541
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