InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPM

Summary

InnateDB Protein

IDBP-24814.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPM

Protein Name

heterogeneous nuclear ribonucleoprotein M

Synonyms

CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000325732

InnateDB Gene

IDBG-24810 (HNRNPM)

Protein Structure

UniProt Annotation

Function

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269Ref.5}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 243 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	243 [view]
Protein-Protein	243 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0042382	paraspeckles
GO:0071013	catalytic step 2 spliceosome