InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MVP

Summary

InnateDB Protein

IDBP-24817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MVP

Protein Name

major vault protein

Synonyms

LRP; VAULT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349977

InnateDB Gene

IDBG-24815 (MVP)

Protein Structure

UniProt Annotation

Function

Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269PubMed:15133037, ECO:0000269PubMed:16418217, ECO:0000269PubMed:16441665}.

Subcellular Localization

Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.

Disease Associations

Tissue Specificity

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0015031	protein transport
GO:0023057	negative regulation of signaling
GO:0031953	negative regulation of protein autophosphorylation
GO:0038127	ERBB signaling pathway
GO:0051028	mRNA transport
GO:0061099	negative regulation of protein tyrosine kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome