Version 5.4
Mus musculus Protein: Rbfox1
Summary
InnateDB Protein IDBP-248753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbfox1
Protein Name RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000111507
InnateDB Gene IDBG-131279 (Rbfox1)
Protein Structure
UniProt Annotation
Function RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. {ECO:0000269PubMed:12574126, ECO:0000269PubMed:15824060, ECO:0000269PubMed:16260614, ECO:0000269PubMed:17101796}.
Subcellular Localization Nucleus. Cytoplasm. Note=Predominantly nuclear.
Disease Associations
Tissue Specificity Detected in brain (at protein level). Detected in heart, brain, neurons, skeletal muscle and embryo. {ECO:0000269PubMed:12574126, ECO:0000269PubMed:15824060, ECO:0000269PubMed:16260614}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
Protein Structure and Domains
PDB ID MGI:1926224
InterPro IPR000504 RNA recognition motif domain
IPR017325 RNA binding protein Fox-1
IPR025670 Fox-1 C-terminal domain
PFAM PF00076
PF12414
PRINTS
PIRSF PIRSF037932
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJ43
PhosphoSite PhosphoSite-Q9JJ43
TrEMBL
UniProt Splice Variant
Entrez Gene 268859
UniGene Mm.398989
RefSeq NP_067452
MGI ID
MGI Symbol Rbfox1
OMIM
CCDS CCDS37245
HPRD
IMGT
EMBL AB041596 AF107204 AF191501 AK134833 AY659954 AY659955 AY659956 AY659957 AY659958 BC059002
GenPept AAF78292 AAH59002 AAL83425 AAV74337 AAV74338 AAV74339 AAV74340 AAV74341 BAA95079 BAE22304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca