InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abat

Summary

InnateDB Protein

IDBP-248757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abat

Protein Name

4-aminobutyrate aminotransferase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111505

InnateDB Gene

IDBG-131633 (Abat)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003867	4-aminobutyrate transaminase activity
GO:0008483	transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0032145	succinate-semialdehyde dehydrogenase binding
GO:0042803	protein homodimerization activity
GO:0047298	(S)-3-amino-2-methylpropionate transaminase activity

Biological Process

GO:0001666	response to hypoxia
GO:0007620	copulation
GO:0007626	locomotory behavior
GO:0009448	gamma-aminobutyric acid metabolic process
GO:0010039	response to iron ion
GO:0035094	response to nicotine
GO:0042135	neurotransmitter catabolic process
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0045776	negative regulation of blood pressure
GO:0048148	behavioral response to cocaine