InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akap4

Summary

InnateDB Protein

IDBP-248953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akap4

Protein Name

A kinase (PRKA) anchor protein 4

Synonyms

AKAP-4; AKAP82; Fsc1; mAKAP82; p82; PRKA4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111417

InnateDB Gene

IDBG-128910 (Akap4)

Protein Structure

UniProt Annotation

Function

Major structural component of sperm fibrous sheath. Plays a role in sperm motility. {ECO:0000269PubMed:12167408}.

Subcellular Localization

Cell projection, cilium, flagellum {ECO:0000250}. Note=Localizes to the principle piece of the sperm flagellum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Spermatid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051018	protein kinase A binding

Biological Process

GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0008104	protein localization
GO:0030030	cell projection organization
GO:0030317	sperm motility

Cellular Component

GO:0005929	cilium
GO:0030018	Z disc
GO:0031514	motile cilium
GO:0035686	sperm fibrous sheath
GO:0048471	perinuclear region of cytoplasm
GO:0097228	sperm principal piece