Version 5.4
Mus musculus Protein: Wdr45
Summary
InnateDB Protein IDBP-249085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr45
Protein Name WD repeat domain 45
Synonyms C79260; DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000111351
InnateDB Gene IDBG-129365 (Wdr45)
Protein Structure
UniProt Annotation
Function Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1859606
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VM3
PhosphoSite PhosphoSite-
TrEMBL F7CAT9
UniProt Splice Variant
Entrez Gene 54636
UniGene Mm.305725
RefSeq XP_006527722
MGI ID
MGI Symbol Wdr45
OMIM
CCDS CCDS29970
HPRD
IMGT
EMBL AF229635 AK008427 AK145616 AL671995 BC011479
GenPept AAF66949 AAH11479 BAB25662 BAE26542 CAM13587 CAM13588

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca