InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Otud5

Summary

InnateDB Protein

IDBP-249126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Otud5

Protein Name

OTU domain containing 5

Synonyms

AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111332

InnateDB Gene

IDBG-129612 (Otud5)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0032496	response to lipopolysaccharide
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination