InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbm3

Summary

InnateDB Protein

IDBP-249245.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbm3

Protein Name

RNA binding motif protein 3

Synonyms

2600016C11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111282

InnateDB Gene

IDBG-130201 (Rbm3)

Protein Structure

UniProt Annotation

Function

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation. {ECO:0000269PubMed:15684048}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in mRNA granules in dentrites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0043023	ribosomal large subunit binding

Biological Process

GO:0006412	translation
GO:0006417	regulation of translation
GO:0009409	response to cold
GO:0035196	production of miRNAs involved in gene silencing by miRNA
GO:0045727	positive regulation of translation