InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Txnrd2

Summary

InnateDB Protein

IDBP-249264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txnrd2

Protein Name

thioredoxin reductase 2

Synonyms

AA118373; ESTM573010; TGR; Tr3; Trxr2; Trxrd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111267

InnateDB Gene

IDBG-141767 (Txnrd2)

Protein Structure

UniProt Annotation

Function

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:10721726}.

Disease Associations

Tissue Specificity

Expressed in liver, heart, testis and kidney. {ECO:0000269PubMed:10455115, ECO:0000269PubMed:10500251, ECO:0000269PubMed:10721726}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0000305	response to oxygen radical
GO:0007507	heart development
GO:0008033	tRNA processing
GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1347023

InterPro

IPR000815 Mercuric reductase
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR002218 Glucose-inhibited division protein A-related
IPR003953 FAD binding domain
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF01134
PF00890
PF07992

PRINTS

PR00945
PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLT4