InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Txnrd2

Summary

InnateDB Gene

IDBG-141767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txnrd2

Gene Name

thioredoxin reductase 2

Synonyms

AA118373; ESTM573010; TGR; Tr3; Trxr2; Trxrd2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000075704

Encoded Proteins

IDBP-249260

thioredoxin reductase 2

IDBP-249262

thioredoxin reductase 2

IDBP-249264

thioredoxin reductase 2

IDBP-706516

IDBP-707426

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product belongs to the family of pyridine nucleotide-disulfide oxidoreductases. It is a mitochondrial enzyme that catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. This protein contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:18426417-18479073

Strand

Forward strand

Band

Transcripts

ENSMUST00000115606	ENSMUSP00000111269
ENSMUST00000115605	ENSMUSP00000111268
ENSMUST00000115604	ENSMUSP00000111267
ENSMUST00000131303
ENSMUST00000126778
ENSMUST00000144233
ENSMUST00000138310
ENSMUST00000149937
ENSMUST00000153457
ENSMUST00000126330
ENSMUST00000156604
ENSMUST00000178093	ENSMUSP00000136373
ENSMUST00000177856	ENSMUSP00000136402

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0000305	response to oxygen radical
GO:0007507	heart development
GO:0008033	tRNA processing
GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000184470

View Gene Order

ENSBTAG00000043581

Not yet available

Pathways

NETPATH

REACTOME

REACT_188957

Cellular responses to stress pathway

REACT_189141

Detoxification of Reactive Oxygen Species pathway

KEGG

mmu00240

Pyrimidine metabolism pathway

mmu00450

Selenocompound metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00450

Selenocompound metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

Q9JLT4

TrEMBL

D3Z0K8 J3QMN4 J3QMQ8

UniProt Splice Variant

Entrez Gene

26462

UniGene

Mm.390906

RefSeq

NM_013711

OMIM

CCDS

HPRD

IMGT

MGI ID

MGI:1347023

MGI Symbol

Txnrd2

EMBL

AB027566 AC133487 AF136399 AF171053 AF412308 AF414356 AF414357 AF414358 AF414359 BC013688 BC052157

GenPept

AAD51323 AAF03359 AAH13688 AAH52157 AAL90457 AAQ03230 BAA86986

RNA Seq Atlas

26462